Complement-Mediated Adherence of Cells to Microfilariae of Brugia Malayi

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  • Department of Medicine, Harvard Medical School, and Department of Rheumatology and Immunology, Brigham and Women's Hospital, and the Center for Blood Research, Boston, Massachusetts 02115
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Immune sera promote the adherence of human buffy coat cells to microfilariae of Brugia malayi. This effect is augmented by the simultaneous addition of fresh human or guinea pig serum. The heat-labile, adherence-promoting factor present in nonimmune sera appears to be complement. In the absence of antibody, microfilariae activate complement via the alternative pathway and C3 is deposited on the microfilarial sheath.

Author Notes

Present address: Departménto de Immunologia e Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Address reprint requests to: Dr. W. F. Piessens, Seeley G. Mudd Building, Room 507, 250 Longwood Avenue, Boston, MA 02115.