A Longitudinal Study of Malaria Antibodies in a Malaysian Population

I. Group Responses

Henry M. MathewsCenters for Disease Control, Public Health Service, U.S. Department of Health and Human Services, U. S. Army Medical Research Unit, Institute for Medical Research, Atlanta, Georgia 30333, Malaysia

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Timothy J. Dondero Jr.Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, U. S. Army Medical Research Unit, Institute for Medical Research, Atlanta, Georgia 30333, Malaysia

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The indirect hemagglutination test was used to measure malaria antibody levels in residents of an endemic area of Malaysia. Blood specimens were collected at 4-week intervals for a year. Seropositivity rates increased with age and number of episodes of malaria in young children. Although antibody levels were variable, titers tended to rise with parasitemia and fall in the absence of detected parasites. In general, the serologic indices tended to reflect the parasitologic findings.

Author Notes

Present address: Centers for Disease Control, Atlanta, Georgia 30333.

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