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Travelers' diarrhea in Bangkok, Thailand was investigated in a group of 146 hotel guests who had diarrhea during their stay in the city. The identified pathogenic organisms were Vibrio parahaemolyticus in 45 (31%), Vibrio cholerae in 1, nonagglutinable Vibrio in 1, and Entamoeba histolytica in 3. Identification of enterotoxigenic Escherichia coli was not attempted. The study suggests that Vibrio parahaemolyticus is a major cause of travelers' diarrhea in Bangkok.