Immunization of Mice with Trypanosoma Rhodesiense Exposed to Ultraviolet Irradiation

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  • Division of Tropical and Geographic Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131

Exposure time of Trypanosoma rhodesiense as short as 1 minute to ultraviolet (U.V.) light prevents the organisms from causing infection. Live trypanosome challenge of mice immunized with U.V.-irradiated trypanosomes results in sterile immunity. This allows a method for the induction of protective immunity to experimental trypanosomiasis which can be performed in most laboratoires using U.V. germicidal lamps found in sterile hoods.