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Effect on Mice of Infection During Pregnancy with Three Australian Arboviruses
John G. Aaskov
John G. Aaskov
Queensland Institute of Medical Research, Bramston Terrace, Herston, Brisbane, Queensland 4006, Australia
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Cherryl E. A. Davies
Cherryl E. A. Davies
Queensland Institute of Medical Research, Bramston Terrace, Herston, Brisbane, Queensland 4006, Australia
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Margaret Tucker
Margaret Tucker
Queensland Institute of Medical Research, Bramston Terrace, Herston, Brisbane, Queensland 4006, Australia
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Debra Dalglish
Debra Dalglish
Queensland Institute of Medical Research, Bramston Terrace, Herston, Brisbane, Queensland 4006, Australia
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Infection of pregnant mice with Ross River or Getah viruses after the establishment of a functional placenta resulted in fetal infection with these viruses. However, only with Ross River virus was there any significant fetal death. There was significant post-partum mortality in mice infected in utero with Ross River but not with Getah virus. In contrast, significant post-partum mortality occurred in Murray Valley encephalitis virus-infected mice despite the inability of the virus to cross the placenta. Infection of mice with Ross River, Getah, or Murray Valley encephalitis viruses before placentation had occurred (5th day postconception) did not result in fetal infection although there was significant post-partum death in litters born to Ross River virus-infected mothers.
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| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 484 | 194 | 44 |
| Full Text Views | 22 | 6 | 0 |
| PDF Downloads | 30 | 9 | 0 |