By Everard L. Napier, M.R.C.S., L.R.C.P. (Lond.). In charge Kala-azar research, Calcutta School of Tropical Medicine. Second edition. 185 pages of text with 15 charts in the text, 18 plates, and an appendix of references to literature, author index and subject index. Oxford University Press. London, Bombay, Calcutta, Madras, 1927
In studying the relationship between time of administration and dose of pyrimethamine against Plasmodium gallinaceum in young chicks, it was found that with single oral doses the infection could be eradicated even if treatment was withheld up to and including day 6. A greater percentage of chicks not cured by early treatment died of exoerythrocytic infection than of those not cured by treatment given later.