Relationship between Time of Administration, Dose, and Prophylactic Activity of Pyrimethamine on Sporozoite-Induced Plasmodium Gallinaceum Infections

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  • National Institutes of Health, National Microbiological Institute, Laboratory of Tropical Diseases, Bethesda 14, Maryland


In studying the relationship between time of administration and dose of pyrimethamine against Plasmodium gallinaceum in young chicks, it was found that with single oral doses the infection could be eradicated even if treatment was withheld up to and including day 6. A greater percentage of chicks not cured by early treatment died of exoerythrocytic infection than of those not cured by treatment given later.