The Effect of Schistosoma Mansoni Infections on Liver Function in Mice

I. Amino Acid Oxidase and Ammonia

Jack DaughertyU. S. Army Tropical Research Medical Laboratory, Rice Institute, San Juan

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Seymour GarsonU. S. Army Tropical Research Medical Laboratory, Rice Institute, San Juan

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Donald HeynemanU. S. Army Tropical Research Medical Laboratory, Rice Institute, San Juan

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Summary

Preliminary studies on the effects of S. mansoni infections in mice gave evidence of an increased liver size, an increased water content of the liver, a decreased oxidative deamination of amino acids, and a failure in ammonia metabolism. These results are discussed in relation to the structural changes in the liver that accompany the infection.

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