Tetrachlorethylene, U.S.P., when administered without being followed by a purge, causes less shock to the patient and is more efficacious in removing hookworms than when the anthelmintic is followed by a saline purge.
A dosage scale of 0.05 cc. tetrachlorethylene per pound of body weight, with a maximum dose of 4.0 cc., is quite efficient in removing hookworms and is safe for the patient. A dosage scale of 0.06 cc. tetrachlorethylene per pound of body weight, with a maximum dose of 5.0 cc., is also highly efficacious and causes no more untoward symptoms than does the smaller dosage.
More than 591,000 treatments have been given to about 385,000 patients using tetrachlorethylene without a purge. Of these, 388,623 treatments were of the first dosage scale indicated above, and 52,611 were of the second dosage scale. At present, the latter is being employed exclusively in our hookworm clinics.
In hookworm-counted, controlled treatments there was no increase in anthelmintic efficiency as a result of alternating treatments with tetrachlorethylene and hexylresorcinol. There was no increase in anthelmintic efficiency as a result of administering the tetrachlorethylene in fractionated doses, nor did emptying the intestine by means of a laxative before the anthelmintic treatment increase its efficacy.
Division of Medicine and Public Health, The Rockefeller Foundation.
Director, Hookworm Control Division, Dominican Republic.
Subdirector, Hookworm Control Division, Dominican Republic.