Antimalarial Activity of Dihydrotriazines

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  • Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.


Data are given regarding the effects of several dihydrotriazines against P. lophurae in ducks or P. berghei in mice. A number of the compounds tested were more active than quinine, primaquine, chlorguanide and chloroquine against P. berghei. Among the most active were 4,6-diamino-1-(3,4-dichlorophenyl)-1,2-dihydro-2-methyl-s-triazine and 4,6-diamino-1-(3,4-dichlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine.