Susceptibility to Chemotherapeutic Agents of Strains of Schistosoma mansoni Isolated from Treated and Untreated Patients

Neusa Araujo Centro de Pesquisas “René Rachou,” Fundação Oswaldo Cruz, Belo Horizonte, Brazil

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Naftale Katz Centro de Pesquisas “René Rachou,” Fundação Oswaldo Cruz, Belo Horizonte, Brazil

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Emmanuel Pinto Dias Centro de Pesquisas “René Rachou,” Fundação Oswaldo Cruz, Belo Horizonte, Brazil

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Cecília Pereira De Souza Centro de Pesquisas “René Rachou,” Fundação Oswaldo Cruz, Belo Horizonte, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1980.29.890
Volume/Issue:
Volume 29: Issue 5
Page(s):
890–894
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Seven strains of Schistosoma mansoni were isolated from the feces of patients. Three of the patients had been unsuccessfully treated with hycanthone or oxamniquine; the remaining four had not been given any specific treatment. Mice infected with these strains were treated 45 days later with niridazole (50 or 100 mg/kg body weight per day for 5 days, per os), hycanthone (single dose of 80 or 160 mg/kg, intramuscularly), or oxamniquine (single dose of 50 or 100 mg/kg, per os). Significant differences in the strains' responses to the schistosomicidal agents used were observed. Oogram changes in mice treated with the same drug ranged from 10–100%, and percentages of dead worms from 0–45. Such differences seemed to be dependent on the strain's specific characters rather than to their having been exposed to schistosomicidal drugs.
Copyright:
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene 1980
Accepted:
15 Oct 1979
|
Published Online:
Sep 1980
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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