Experimental Infection of Sheep with Naegleria fowleri of Human Origin

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  • Department of Preventive Medicine, College of Veterinary Medicine, and Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, and Medical Research Service, Veterans Administration Medical Center, Gainesville, Florida 32610

A strain of Naegleria fowleri, isolated from a child who died of primary amebic meningoencephalitis in Florida, was instilled in the nostrils of a sheep to determine whether livestock are susceptible to infection with free-living amebae. The animal died 7 days later from amebic infection of the central nervous system. N. fowleri were recovered from the brain and spinal cord of the animal. A control, saline-instilled sheep that had been pair-caged with the infected animal remained helathy.