Observations on Cattle Schistosomiasis in the Sudan, a Study in Comparative Medicine

III. Field Testing of an Irradiated Schistosoma Bovis Vaccine

A. A. Majid Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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H. O. Bushara Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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A. M. Saad Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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M. F. Hussein Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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M. G. Taylor Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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J. D. Dargie Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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T. F. de C. Marshall Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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G. S. Nelson Department of Veterinary Pathology, Faculty of Veterinary Science, University of Khartoum, Department of Medical Helminthology and Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Glasgow, Khartoum, Sudan

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DOI:
https://doi.org/10.4269/ajtmh.1980.29.452
Volume/Issue:
Volume 29: Issue 3
Page(s):
452–455
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Previous work has shown that cattle can acquire a strong resistance to Schistosoma bovis infection following repeated natural exposure. Partial resistance to a laboratory challenge with S. bovis has also been demonstrated in calves after immunization with an irradiated schistosomular or cercarial vaccine. The aim of the present study was to see whether this type of vaccine could protect calves under the very different conditions of natural exposure to S. bovis in the field. Thirty 6- to 9-month-old calves were each immunized with 10,000 irradiated S. bovis schistosomula by intramuscular injection and 8 weeks later were released into an enzootic area along with 30 unvaccinated animals. The calves were followed up for 10 months, during which period protection was evidenced by a lower mortality rate, a slower rate of acquisition of infection, and lower fecal egg counts in the vaccinated calves. Necropsy of the survivors showed 60–70% reductions in worm and tissue egg counts of the vaccinated calves as compared to those not vaccinated.

Author Notes

Copyright:
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene 1980
Accepted:
01 Sep 1979
|
Published Online:
May 1980
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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