Therapeutic Efficacy of Oral Oxamniquine in the Toxemic form of Schistosomiasis Mansoni: Treatment of Eleven Individuals from Two Families, and Experimental Study

José Roberto Lambertucci Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Enio Roberto Pietra Pedroso Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Dirceu Wagner Carvalho de Souza Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Davidson Pires de Lima Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Jayme Neves Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Herculano Mourão Salazar Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Roberto Pedercini Marinho Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Manoel Otávio da Costa Rocha Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Paulo Marcos Zech Coelho Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Maria Fernanda Furtado de Lima Costa Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Dirceu Bartolomeu Greco Faculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1980.29.50
Volume/Issue:
Volume 29: Issue 1
Page(s):
50–53
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Two families, comprising 11 individuals in the toxemic form of schistosomiasis mansoni, infected in Belo Horizonte, Brazil were treated. Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil®), 20 mg/kg body weight. No significant side effects were observed. To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with miracidia from eggs obtained from three of the individuals not cured were studied. Mice infected with these three strains were cured after a single oral dose of oxamniquine. It is suggested that research be continued with other therapeutic schedules and perhaps other, more potent, drugs.

Author Notes

Accepted:
19 May 1979
|
Published Online:
Jan 1980
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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