Therapeutic Efficacy of Oral Oxamniquine in the Toxemic form of Schistosomiasis Mansoni: Treatment of Eleven Individuals from Two Families, and Experimental Study

José Roberto LambertucciFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Enio Roberto Pietra PedrosoFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Dirceu Wagner Carvalho de SouzaFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Davidson Pires de LimaFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Jayme NevesFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Herculano Mourão SalazarFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Roberto Pedercini MarinhoFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Manoel Otávio da Costa RochaFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Paulo Marcos Zech CoelhoFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Maria Fernanda Furtado de Lima CostaFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Dirceu Bartolomeu GrecoFaculdade de Medicina da Universidad Federal de Minas Gerais, Alameda Alvaro Celso, 117, 30000 Belo Horizonte, Minas Gerais, Brazil

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Two families, comprising 11 individuals in the toxemic form of schistosomiasis mansoni, infected in Belo Horizonte, Brazil were treated. Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil®), 20 mg/kg body weight. No significant side effects were observed. To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with miracidia from eggs obtained from three of the individuals not cured were studied. Mice infected with these three strains were cured after a single oral dose of oxamniquine. It is suggested that research be continued with other therapeutic schedules and perhaps other, more potent, drugs.

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