Demonstration of Dengue Antibody Complexes on the Surface of Platelets from Patients with Dengue Hemorrhagic Fever

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  • Department of Pathobiology, Faculty of Science, and Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Children's Hospital, Bangkok, Thailand

By the direct immunofluorescent technic, dengue antigen, human immunoglobulins, and β1C globulin were detectable on the surfaces of platelet suspensions from 48% of patients with dengue hemorrhagic fever. The percentages of positive-staining platelets were not related to the severity of thrombocytopenia, which was marked on the day after the patient developed shock or subsidence of fever. It is suggested that an immunologic mechanism is one of the factors associated with the thrombocytopenia caused by increased platelet destruction.