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Damage to Trichinella Spiralis Newborn Larvae by Eosinophil Major Basic Protein

Donald L. WassomAllergic Diseases Research Laboratory, Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55901

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Gerald J. GleichAllergic Diseases Research Laboratory, Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55901

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Purified eosinophil major basic protein damaged newborn larvae of Trichinella spiralis when added to in vitro cultures. Damaged larvae were stiffened, immobile, and showed a granular appearance by light microscopy. Larvae in control cultures and in cultures containing equimolar concentrations of other basic proteins failed to exhibit such damage.

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