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Serological Differences between Acute and Chronic Schistosomiasis Mansoni Detected by Enzyme-Linked Immunosorbent Assay (Elisa)
Milford N. Lunde
Milford N. Lunde
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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Eric A. Ottesen
Eric A. Ottesen
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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Allen W. Cheever
Allen W. Cheever
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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Sera from patients with acute and chronic schistosomiasis mansoni, and from laboratory-infected monkeys, were examined by an enzyme-linked immunosorbent assay technique using antigens prepared from eggs, cercariae, and adult worms. Sera from patients with acute schistosomiasis and from monkeys 2 months post-infection reacted more positively to cercarial antigen than to adult worm antigen whereas sera from both patients with chronic schistosomiasis and monkeys infected for longer than 4 months reacted more positively to adult worm antigen. These differential responses to antigen serologically differentiated between acute and chronic schistosome infections.
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| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 674 | 361 | 19 |
| Full Text Views | 9 | 1 | 0 |
| PDF Downloads | 9 | 2 | 0 |