Transovarial Transmission of Yellow Fever Virus by Mosquitoes (Aedes Aegypti)

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  • Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 60 College Street, New Haven, Connecticut 06510
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Female Aedes aegypti mosquitoes infected with yellow fever virus by intra-thoracic inoculation transmitted the virus to a small percentage of their F1 progeny. Infected offspring were obtained from surface-sterilized as well as from untreated eggs, indicating that the virus was transovarially transmitted. Vertical transmission of yellow fever virus in mosquitoes may be an alternative mechanism for biological survival of the virus during adverse periods or in the absence of susceptible vertebrate hosts.