Partial Protection of Plasmodium Falciparum-Vaccinated Aotus Trivirgatus against a Challenge of a Heterologous Strain

Wasim A. SiddiquiDepartment of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816

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Diane W. TaylorDepartment of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816

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Siu-Chow KanDepartment of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816

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Kenton KramerDepartment of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816

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Suzanne Richmond-CrumDepartment of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816

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Two Aotus trivirgatus griseimenbra monkeys which had been immunized with the merozoite-enriched FUP strain of Plasmodium falciparum were protected against a primary challenge with the homologous strain. The results described here show that these two monkeys were protected against a subsequent challenge with a heterologous strain (FVO) of P. falciparum. The unimmunized control monkey died of FVO infection by day 18.

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