Resistance of Mice to Secondary Infection with Schistosoma Mansoni

I. Comparison of Bisexual and Unisexual Initial Infections

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  • Immunoparasitology Department, Naval Medical Research Institute, American Foundation for Biological Research, Bethesda, Maryland
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Mice receiving a unisexual primary infection with either sex of Schistosoma mansoni did not develop detectable resistance to reinfection. In contrast, mice receiving a bisexual primary infection developed a high degree of resistance. The number of adult worms developing from the challenge infection was reduced, relative to controls, by 72–100% at challenge times of 6 weeks or greater.