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Immunoglobulins (Igs) reacting against endothelial and vascular structures and striated muscle cells as well as against cells from a peripheral nerve were detected by indirect immunofluorescent test (IIF) in a rhesus monkey infected for 29 yr with Trypanosoma cruzi. Anti-T. cruzi antibodies in this monkey showed a titer of 1:128 in the IIF test and the direct agglutination test. Tissue-reacting Igs were bound in vivo to the tissues, as was established by direct treatment of a biopsy of the deltoid muscle with Ig-labeled antisera. Electron microscopy of this tissue showed that Igs reacted with the plasma membrane of the muscle cells. Neither tissue-reacting Igs nor specific antibodies were detected in three uninfected adult monkeys.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 627 | 349 | 18 |
Full Text Views | 5 | 1 | 1 |
PDF Downloads | 2 | 0 | 0 |