Tissue Reacting Antibodies in a Rhesus Monkey with Long-Term Trypanosoma Cruzi Infection

A. Szarfman Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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F. S. Laranja Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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W. de Souza Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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L. Galvão Quintao Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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D. Gerecht Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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G. A. Schmuñis Institute of Microbiology and Institute of Biophysics, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1978.27.832
Volume/Issue:
Volume 27: Issue 4
Page(s):
832–834
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Immunoglobulins (Igs) reacting against endothelial and vascular structures and striated muscle cells as well as against cells from a peripheral nerve were detected by indirect immunofluorescent test (IIF) in a rhesus monkey infected for 29 yr with Trypanosoma cruzi. Anti-T. cruzi antibodies in this monkey showed a titer of 1:128 in the IIF test and the direct agglutination test. Tissue-reacting Igs were bound in vivo to the tissues, as was established by direct treatment of a biopsy of the deltoid muscle with Ig-labeled antisera. Electron microscopy of this tissue showed that Igs reacted with the plasma membrane of the muscle cells. Neither tissue-reacting Igs nor specific antibodies were detected in three uninfected adult monkeys.

Author Notes

Copyright:
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene 1978
Accepted:
20 Jan 1978
|
Published Online:
Jul 1978
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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