Comparative Evaluation of Two Dosages of Tinidazole in the Treatment of Giardiasis

A. M. M. Jokipii Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland

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Liisa Jokipii Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland

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DOI:
https://doi.org/10.4269/ajtmh.1978.27.758
Volume/Issue:
Volume 27: Issue 4
Page(s):
758–761
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Forty-five patients with parasitologically confirmed symptomatic giardiasis were treated with tinidazole. A course of 150 mg twice daily for 7 days cured 14 of 19 patients (74%), and a single dose of 2,000 mg cured 24 of 26 (92%). After the single dose, mild side effects were common including maltaste, lassitude, and dizziness. Three probable cases of the so-called “postgiardiac syndrome” were seen. Either dosage of tinidazole initially cleared all stool samples of Giardia lamblia, and most clinical and parasitological failures were first detected a few weeks after the treatment. This emphasizes the significance of long follow-up periods.
Copyright:
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene 1978
Accepted:
18 Jan 1978
|
Published Online:
Jul 1978
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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