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A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime®). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.
Present address: School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014.
Present address: Animal Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701.
Department of Parasitology, College of Veterinary Medicine, University of Georgia.
Department of Pathology, College of Veterinary Medicine, University of Georgia.