Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 208 85 3
Full Text Views 5 0 0
PDF Downloads 4 0 0
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

The Antileishmanial Activity of Lepidines

Kenneth E. KinnamonDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by Kenneth E. Kinnamon in
Current site
Google Scholar
PubMedClose
,
Edgar A. SteckDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by Edgar A. Steck in
Current site
Google Scholar
PubMedClose
,
Peter S. LoizeauxDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by Peter S. Loizeaux in
Current site
Google Scholar
PubMedClose
,
William L. HansonDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by William L. Hanson in
Current site
Google Scholar
PubMedClose
,
Willie L. Chapman Jr.Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by Willie L. Chapman Jr. in
Current site
Google Scholar
PubMedClose
, and
Virginia B. WaitsDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

Search for other papers by Virginia B. Waits in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.4269/ajtmh.1978.27.751
Volume/Issue:
Volume 27: Issue 4
Page(s):
751–757
Restricted access
Get Permissions

A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime®). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.

Author Notes

Present address: School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014.

Present address: Animal Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701.

Department of Parasitology, College of Veterinary Medicine, University of Georgia.

Department of Pathology, College of Veterinary Medicine, University of Georgia.

Copyright:
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene 1978
Accepted:
11 Mar 1978
|
Published Online:
Jul 1978
Save