The Antileishmanial Activity of Lepidines

Kenneth E. Kinnamon Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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Edgar A. Steck Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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Peter S. Loizeaux Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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William L. Hanson Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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Willie L. Chapman Jr. Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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Virginia B. Waits Division of Medicinal Chemistry, Walter Reed Army Institute of Research, College of Veterinary Medicine, University of Georgia, Washington, D.C. 20012

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DOI:
https://doi.org/10.4269/ajtmh.1978.27.751
Volume/Issue:
Volume 27: Issue 4
Page(s):
751–757
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A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime®). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.

Author Notes

Present address: School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014.

Present address: Animal Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701.

Department of Parasitology, College of Veterinary Medicine, University of Georgia.

Department of Pathology, College of Veterinary Medicine, University of Georgia.

Copyright:
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene 1978
Accepted:
11 Mar 1978
|
Published Online:
Jul 1978
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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