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Strongyloides Ratti Infections in Rats
II. Effects of Cortisone Treatment
C. Erik Olson
C. Erik Olson
Department of Pathobiology, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205
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Everett L. Schiller
Everett L. Schiller
Department of Pathobiology, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205
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Cortisone (5 mg daily subcutaneously) suppressed both primary and secondary immune expulsion of Strongyloides ratti, and reduced the intestinal mast cell response, but did not induce hyperinfection in rats. Cortisone-treated animals expelled primary worm burdens without complication about 2 wk after steroid treatment. A model for gastrointestinal hypersensitivity syndromes is discussed.
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