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Immunoglobulin Concentration in Treated Human Acute Chagas' Disease
A Follow-up Study
Gabriel A. Schmuñis
Gabriel A. Schmuñis
Instituto de Patologia Regional, UNNE and Hospital “A. Castelan,”, Resistencia, Chaco, Argentina
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Ana Szarfman
Ana Szarfman
Instituto de Patologia Regional, UNNE and Hospital “A. Castelan,”, Resistencia, Chaco, Argentina
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Leopoldo Coarasa
Leopoldo Coarasa
Instituto de Patologia Regional, UNNE and Hospital “A. Castelan,”, Resistencia, Chaco, Argentina
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Clara Vainstok
Clara Vainstok
Instituto de Patologia Regional, UNNE and Hospital “A. Castelan,”, Resistencia, Chaco, Argentina
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Immunoglobulin M, G, and A concentrations were studied by radial immunodiffusion technique in 16 individuals (two were 16 and 14 yr of age, respectively, while the remaining 14 were 12 yr of age or less) with acute Trypanosoma cruzi infection. Serum samples were obtained from these patients beginning with the onset of symptoms and continuing until several months after treatment with nifurtimox was completed. Soon after infection the concentration of IgM was higher than the average found in healthy children. Some of the samples also had higher values than those found in children with other acute infections. At this time isolated increases in IgG and/or IgA concentrations were also found in T. cruzi-infected patients. Immunoglobulin concentrations had usually returned to normal when treatment with nifurtimox was completed, both in the patients with negative serology and in those who remained positive. However, some of the sera showed isolated higher IgM, IgG, and/or IgA values than those found in healthy controls.
Author Notes
Member of the research worker career from CONICET. Present address: Institute of Microbiology, University of Rio de Janeiro, Cidade Universitaria, Ilha do Fundão, 20000 Rio de Janeiro, R.J., Brasil.
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