Chemoprophylaxis and Malaria in American Servicemen Returning from Vietnam

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  • Iowa City Veterans Administration Hospital and Department of Internal Medicine, College of Medicine, The University of Iowa, Iowa City, Iowa 52240
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Information relating to chemoprophylaxis and malaria in 49 men who served with the United States Armed Forces in Vietnam and who developed overt malaria after departure from Vietnam indicated that: 1) compliance with intended chemoprophylactic regimens was far from optimal; 2) a history of recent prophylactic ingestion of chloroquine was not a reliable indicator of infection with chloroquine-resistant Plasmodium falciparum; 3) reported ingestion of half or more of an intended terminal chemoprophylactic regimen was associated with a prolongation of the time that elapsed before initial post-departure episodes of vivax malaria; and 4) such partial compliance with intended terminal chemoprophylaxis may have been associated with a decreased incidence of second post-departure episodes of vivax malaria.

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