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IgM and Antibody Measurement in the Diagnosis and Management of Gambian Trypanosomiasis
H. C. Whittle
H. C. Whittle
Department of Medicine, Ahmadu Bello University Hospital, Nuffield Institute of Comparative Medicine, Zoological Society of London, Zaria, Nigeria
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B. M. Greenwood
B. M. Greenwood
Department of Medicine, Ahmadu Bello University Hospital, Nuffield Institute of Comparative Medicine, Zoological Society of London, Zaria, Nigeria
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D. E. Bidwell
D. E. Bidwell
Department of Medicine, Ahmadu Bello University Hospital, Nuffield Institute of Comparative Medicine, Zoological Society of London, Zaria, Nigeria
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Ann Bartlett
Ann Bartlett
Department of Medicine, Ahmadu Bello University Hospital, Nuffield Institute of Comparative Medicine, Zoological Society of London, Zaria, Nigeria
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A. Voller
A. Voller
Department of Medicine, Ahmadu Bello University Hospital, Nuffield Institute of Comparative Medicine, Zoological Society of London, Zaria, Nigeria
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Serum and cerebrospinal fluid (CSF) IgM were measured in 182 patients at various stages of Gambian sleeping sickness and correlated with antibody levels measured by enzyme-linked immunosorbent assay (ELISA). Each of these tests in serum gave a 30% false negative result, but when both were used this fell to 12%. Measurements of IgM in CSF were raised in 87% of patients with advanced disease and in none of the early cases. The IgM levels fell slowly to normal by 12 months after treatment. A high level at this time, or a rise after treatment, was helpful in diagnosing relapsed patients. Antibody levels in CSF were of no use in diagnosis or prognosis, and were raised in many controls.
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| Past two years | Past Year | Past 30 Days | |
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