“Immunology of Schistosoma Mansoni Infection”: Workshop Report II

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  • University of Pennsylvania, School of Medicine, The Veterans Administration Hospital and Department of Microbiology, Vanderbilt University, Philadelphia, Pennsylvania 19174
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The second annual informal Elvio H. Sadun Memorial Workshop on the “Immunology of Schistosoma mansoni Infection” was held on 3 November 1976, in conjunction with the joint meetings of the American and Royal Societies of Tropical Medicine and Hygiene in Philadelphia, Pennsylvania. The following report represents a brief synopsis of that meeting.

Dr. W. M. Kemp began the session by describing ultrastructural studies which localized host immunoglobulins on the tegumental surfaces of adult Schistosoma mansoni worms obtained from mice. Immunocytochemical studies, utilizing immunoglobulin class specific antisera labeled with lactoperoxidase, indicated the presence of mouse IgG1, IgG2a, IgA, and IgM on the surface of worms. While there may be some specific anti-schistosome antibody present, additional evidence, obtained by prior sensitization of the host and agglutination-rosette studies, indicated that much of the surface immunoglobulin had specificties for antigens which are not uniquely restricted to the schistosome.