Tinidazole Treatment of Acute Amebic Dysentery in Children

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  • Department of Paediatrics and Child Health and Institute for Parasitology, South African Medical Research Council, University of Natal, Natal, South Africa
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Tinidazole, a recent derivative of the nitroimidazole group of compounds, was able to achieve a cure in 96% of children with acute amebic dysentery when given in three single daily doses of approximately 60 mg/kg of body weight. At a dose of approximately 50 mg/kg the cure rate was only 76%. The drug was well tolerated and completely free from any toxic effects. Tinidazole can confidently be recommended as a very simple and safe form of therapy for amebic dysentery.