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Tinidazole Treatment of Acute Amebic Dysentery in Children
J. N. Scragg
J. N. Scragg
Department of Paediatrics and Child Health and Institute for Parasitology, South African Medical Research Council, University of Natal, Natal, South Africa
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E. M. Proctor
E. M. Proctor
Department of Paediatrics and Child Health and Institute for Parasitology, South African Medical Research Council, University of Natal, Natal, South Africa
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Tinidazole, a recent derivative of the nitroimidazole group of compounds, was able to achieve a cure in 96% of children with acute amebic dysentery when given in three single daily doses of approximately 60 mg/kg of body weight. At a dose of approximately 50 mg/kg the cure rate was only 76%. The drug was well tolerated and completely free from any toxic effects. Tinidazole can confidently be recommended as a very simple and safe form of therapy for amebic dysentery.
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