Some Observations on Complement Fixation in Onchocerciasis in Guatemalans

Anne A. MacRaeDepartments of Epidemiology and International Health, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205

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Robert I. AndersonDepartments of Epidemiology and International Health, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205

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Louis E. FazenDepartments of Epidemiology and International Health, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205

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Recent investigations of infections with Onchocerca volvulus in Guatemala presented the opportunity to study some aspects of complement fixation (CF) antibody titers. An extract of adult O. volvulus obtained from nodules excised from patients was used as antigen. Serum was procured from individuals whose intensity of infection was determined by skin snip counts of microfilariae. In general there was an inverse relationship between intensity of infection and CF titers. This correlation was significant in men 40 years and older. The CF titer of women was greater than that of men with the same intensity of infection.

Author Notes

Present address: The Johns Hopkins Hospital, Room 625 Osler Building, 601 North Broadway, Baltimore, Maryland 21205.

Present address: Route 4, Box 422, Easton, Maryland 21601.

Present address: University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01605.

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