Clinical Trials of a New Anthelmintic, 4-Isothiocyanato-4′-Nitrodiphenylamine (C.9333-Go/CGP 4540), for the Cure of Hookworm Infection

Jayant C. Doshi Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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Ashok B. Vaidya Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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Himansu G. Sen Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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Niranjan A. Mankodi Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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C. N. Nair Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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R. S. Grewal Dr. R. N. Cooper Municipal General Hospital, CIBA-GEIGY Research Centre, Bombay, India

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DOI:
https://doi.org/10.4269/ajtmh.1977.26.636
Volume/Issue:
Volume 26: Issue 4
Page(s):
636–639
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A new compound, 4-isothiocyanato-4′-nitrodiphenylamine (C.9333-Go/CGP 4540), was tried in 39 hospitalized patients with hookworm infection, using several treatment schedules. At effective dose schedules (125 mg × 3 given 4-hourly; 250 mg × 3, 8-hourly; 1,000 mg × 3, 12-hourly), the egg reduction was 96% to 100%; the zero egg-counts were confirmed by coproculture for larvae. The compound was very well tolerated. Transient and mild side effects—giddiness, diarrhea and sweating—were observed in only three patients. No toxic effects were seen as judged by serial organ function tests, except a transient and mild asymptomatic elevation of transminases in one patient.

Author Notes

Copyright:
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene 1977
Accepted:
15 Dec 1976
|
Published Online:
Jul 1977
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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