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Clinical Trials of a New Anthelmintic, 4-Isothiocyanato-4′-Nitrodiphenylamine (C.9333-Go/CGP 4540), for the Cure of Hookworm Infection
A new compound, 4-isothiocyanato-4′-nitrodiphenylamine (C.9333-Go/CGP 4540), was tried in 39 hospitalized patients with hookworm infection, using several treatment schedules. At effective dose schedules (125 mg × 3 given 4-hourly; 250 mg × 3, 8-hourly; 1,000 mg × 3, 12-hourly), the egg reduction was 96% to 100%; the zero egg-counts were confirmed by coproculture for larvae. The compound was very well tolerated. Transient and mild side effects—giddiness, diarrhea and sweating—were observed in only three patients. No toxic effects were seen as judged by serial organ function tests, except a transient and mild asymptomatic elevation of transminases in one patient.