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Differences in the Virulence of Plasmodium Knowlesi for Macaca Irus (Fascicularis) of Philippine and Malayan Origins
L. H. Schmidt
L. H. Schmidt
The Christ Hospital Institute for Medical Research, National Center for Primate Biology, University of California, Kettering-Meyer Laboratory, Southern Research Institute, Cincinnati, Ohio 45219
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Rochelle Fradkin
Rochelle Fradkin
The Christ Hospital Institute for Medical Research, National Center for Primate Biology, University of California, Kettering-Meyer Laboratory, Southern Research Institute, Cincinnati, Ohio 45219
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Janet Harrison
Janet Harrison
The Christ Hospital Institute for Medical Research, National Center for Primate Biology, University of California, Kettering-Meyer Laboratory, Southern Research Institute, Cincinnati, Ohio 45219
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Richard N. Rossan
Richard N. Rossan
The Christ Hospital Institute for Medical Research, National Center for Primate Biology, University of California, Kettering-Meyer Laboratory, Southern Research Institute, Cincinnati, Ohio 45219
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This report summarizes the results of a comparative study of the virulence of the “S-M,” H, and C strains of P. knowlesi for Indian rhesus monkeys (Macaca mulatta) and cynomolgus monkeys [M. irus (fascicularis)] of Malayan (West Malaysia) and Philippine origins. Each of the above strains produced fulminating, uniformly fatal infections in the rhesus monkey and mild, chronic infections, characterized by relatively low level parasitemias in cynomolgus monkeys of Philippine origin. In striking contrast, the H and C strains produced infections in cynomolgus monkeys of Malayan origin which were indistinguishable in severity from infections produced in M. mulatta. The circumstances of the study precluded evaluation of the virulence of the “S-M” strain for M. irus of Malayan origin. Even so, the available data make it necessary to qualify the long-held belief that infections with P. knowlesi in M. irus invariably follow a benign course.
Author Notes
Present address: Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama.
Present address: Children's Hospital Research Foundation, Cincinnati, Ohio.
Present address: Department of Pediatrics, College of Medicine, University of California, Davis, California.
Present address: Gorgas Memorial Laboratory, Balboa Heights, Canal Zone.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1142 | 831 | 13 |
| Full Text Views | 22 | 1 | 0 |
| PDF Downloads | 25 | 1 | 0 |