Proteolytic, Antigenic and Immunogenic Properties of Schistosoma mansoni Cercarial Secretion Material

Patricia Minard Department of Clinical and Experimental Immunology, Naval Medical Research Institute, American Federation for Biological Research, Bethesda, Maryland 20014

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K. Darwin Murrell Department of Clinical and Experimental Immunology, Naval Medical Research Institute, American Federation for Biological Research, Bethesda, Maryland 20014

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Margaret A. Stirewalt Department of Clinical and Experimental Immunology, Naval Medical Research Institute, American Federation for Biological Research, Bethesda, Maryland 20014

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Schistosoma mansoni cercariae secrete preacetabular gland material in association with skin penetration. The material is heterogeneous and contains proteolytic enzyme(s) which comprise a small proportion of the total protein. We have immunized mice with cercarial secretion material in several protocols designed to induce a variety of antibody responses. The cercarial secretion material is sufficiently immunogenic to induce precipitating and reaginic antibody production. The antibodies obtained were not of the necessary quantity and/or quality to afford protection from a challenge infection.

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