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Coagulation Factor XIIa (Activated Hageman Factor) Inhibitor from Adult Schistosoma Mansoni
Victor C. W. Tsang
Victor C. W. Tsang
Department of Zoology, University of Georgia, Athens, Georgia 30602
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William J. Hubbard
William J. Hubbard
Department of Zoology, University of Georgia, Athens, Georgia 30602
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Raymond T. Damian
Raymond T. Damian
Department of Zoology, University of Georgia, Athens, Georgia 30602
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An inhibitory activity for the contact phase of the intrinsic coagulation pathway was demonstrated in an extract of adult Schistosoma mansoni. Inhibition is apparently specific for the enzymatic activation of Factor XI (pre-PTA) by Factor XIIa (activated Hageman factor). This phenomenon offers an explanation for the schistosomal evasive mechanism of the host contact hemostatic defense system.
Author Notes
Submitted as partial fulfillment for the degree of Ph.D. from the University of Georgia, Zoology Department.
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