Adaptation of a Microimmunofluorescence Test to the Study of Human Rickettsia Tsutsugamushi Antibody

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  • U. S. Army Medical Research Unit, Institute for Medical Research, Kuala Lumpur, Malaysia

A microimmunofluorescence (micro-IFA) test has been adapted to the study of naturally occurring antibody to Rickettsia tsutsugamushi in humans. The micro-IFA test was comparable to the present immunofluorescent assay in sensitivity and reproducibility, but offered distinct advantages in the quantity of reagents necessary. Also the micro-IFA could be used to simultaneously titer a serum to as many as nine strains of the organism resulting in a great saving of time.