Mebendazole in Treatment of Severe Trichuris trichiura Infection in Malaysian Children

Iyngkaran Nagalingam Department of Paediatrics, University Hospital, Kuala Lumpur, Malaysia

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Lee Eng Lam Department of Paediatrics, University Hospital, Kuala Lumpur, Malaysia

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Maxwell J. Robinson Department of Paediatrics, University Hospital, Kuala Lumpur, Malaysia

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A. S. Dissanaike Department of Paediatrics, University Hospital, Kuala Lumpur, Malaysia

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DOI:
https://doi.org/10.4269/ajtmh.1976.25.568
Volume/Issue:
Volume 25: Issue 4
Page(s):
568–572
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Children with severe Trichuris trichiura infection pose significant social, clinical, and therapeutic problems in Malaysia. Thirty such children were investigated, and mebendazole was found to be safe and effective in the treatment of severe trichuriasis but it had to be given for a longer period than currently recommended. A poor correlation was found between egg load and worm burden in these children. Direct visualization of the rectal and colonic mucosa was the most reliable method of assessing severity in untreated cases, and response to treatment. The eggs of Trichuris that had been exposed to mebendazole were morphologically altered and not viable when incubated. This may be of considerable epidemiological importance.

Author Notes

Copyright:
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene 1976
Accepted:
09 Feb 1976
|
Published Online:
Jul 1976
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Diagnostic Procedures and Reagents

Technics for the Laboratory Diagnosis and Control of the Communicable Diseases, American Public Health Association, Ed., pp. v plus 589, 6 plates in color, cloth, New York, Am. Pub. Health Assoc. Inc., 1950, $6.00

An Introduction to Medical Protozoology

With Chapters on the Spirochaetes and on Laboratory Methods. By Robert Knowles, B.A., M.R.C.S., L.R.C.P., Lt. Col., Indian Medical Service, Calcutta. Thacker, Spink and Company. 1928. Pages I–XII, 1–887

Author:
Chas. F. Craig
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