Therapeutic Evaluation of Oxantel Pamoate (1,4,5,6-Tetrahydro-1-Methyl-2-[Trans-3-Hydroxystyryl] Pyrimidine Pamoate) in Severe Trichuris trichiura Infection

Eng-Lam Lee Departments of Paediatrics and Parasitology, University of Malaya, Kuala Lumpur, Malaysia

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N. Iyngkaran Departments of Paediatrics and Parasitology, University of Malaya, Kuala Lumpur, Malaysia

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Andrew W. Grieve Departments of Paediatrics and Parasitology, University of Malaya, Kuala Lumpur, Malaysia

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Maxwell J. Robinson Departments of Paediatrics and Parasitology, University of Malaya, Kuala Lumpur, Malaysia

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Anselm S. Dissanaike Departments of Paediatrics and Parasitology, University of Malaya, Kuala Lumpur, Malaysia

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DOI:
https://doi.org/10.4269/ajtmh.1976.25.563
Volume/Issue:
Volume 25: Issue 4
Page(s):
563–567
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The efficacy of oxantel pamoate (1,4,5,6-tetrahydro-2-[trans-3-hydroxystyryl]-1-methyl pyrimidine pamoate) was evaluated in 25 children with severe Trichuris infection. The presence of chronic dysentery and sigmoidoscopic demonstration of whipworms in the intestinal mucosa were the criteria for inclusion in the trial. Most of these patients had severe anemia, rectal prolapse, digital clubbing, hypoproteinemia, and growth retardation. There was a high incidence of concomitant parasitism with other intestinal helminths and with Entamoeba histolytica and Giardia lamblia. Sigmoidoscopic grading of Trichuris load and egg count in the feces were carried out prior to treatment and 2 days after each course of oxantel therapy. Oxantel was administered at a dose of 10 mg/kg body weight twice daily for a 3-day course. Satisfactory response, as judged by relief of dysentery and absence of whipworms from the mucosa at sigmoidoscopy, was achieved in 17 patients after the first course and in the remaining 8 patients after a second course of oxantel. The drug was well tolerated and no side effects were noted during or after treatment. It is concluded that oxantel is a safe and effective anthelmintic for severe clinical trichuriasis.

Author Notes

Copyright:
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene 1976
Accepted:
29 Nov 1975
|
Published Online:
Jul 1976
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Diagnostic Procedures and Reagents

Technics for the Laboratory Diagnosis and Control of the Communicable Diseases, American Public Health Association, Ed., pp. v plus 589, 6 plates in color, cloth, New York, Am. Pub. Health Assoc. Inc., 1950, $6.00

An Introduction to Medical Protozoology

With Chapters on the Spirochaetes and on Laboratory Methods. By Robert Knowles, B.A., M.R.C.S., L.R.C.P., Lt. Col., Indian Medical Service, Calcutta. Thacker, Spink and Company. 1928. Pages I–XII, 1–887

Author:
Chas. F. Craig
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