Double-Blind Test of Metronidazole and Tinidazole in the Treatment of Asymptomatic Entamoeba histolytica and Entamoeba hartmanni Carriers

Rupert Spillmann Tulane University International Center for Medical Research, Parasitology Section, Universidad del Valle Medical School, Apartado Aereo 5390, Cali, Colombia

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Stephen C. Ayala Tulane University International Center for Medical Research, Parasitology Section, Universidad del Valle Medical School, Apartado Aereo 5390, Cali, Colombia

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Carmen Elena de Sanchez Tulane University International Center for Medical Research, Parasitology Section, Universidad del Valle Medical School, Apartado Aereo 5390, Cali, Colombia

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DOI:
https://doi.org/10.4269/ajtmh.1976.25.549
Volume/Issue:
Volume 25: Issue 4
Page(s):
549–551
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One hundred and fifteen persons with asymptomatic Entamoeba histolytica or E. hartmanni infection, or both, were given metronidazole (750 mg three times daily for 5 days), tinidazole (1 g twice daily on 2 consecutive days), or a starch placebo. Three posttreatment stools were examined in the 2 weeks following initiation of treatment. Cysts of E. histolytica reappeared in the stools of 37% of 30 given metronidazole, 62% of 34 given tinidazole, and 70% of 31 given placebo. Cysts of E. hartmanni reappeared in the stools of 46% of 24 given metronidazole, 69% of 16 given tinidazole, and 90% of 10 given placebo. Rapid absorption and short duration of treatment make both drugs ineffective for the treatment of ameba carriers.

Author Notes

Copyright:
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene 1976
Accepted:
06 Dec 1975
|
Published Online:
Jul 1976
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Diagnostic Procedures and Reagents

Technics for the Laboratory Diagnosis and Control of the Communicable Diseases, American Public Health Association, Ed., pp. v plus 589, 6 plates in color, cloth, New York, Am. Pub. Health Assoc. Inc., 1950, $6.00

An Introduction to Medical Protozoology

With Chapters on the Spirochaetes and on Laboratory Methods. By Robert Knowles, B.A., M.R.C.S., L.R.C.P., Lt. Col., Indian Medical Service, Calcutta. Thacker, Spink and Company. 1928. Pages I–XII, 1–887

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Chas. F. Craig
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