Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Clinical and Laboratory changes Consequent to Diethylcarbamazine in Patients with Onchocerciasis

Louis E. FazenDepartment of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, Onchocerciasis Section, Division of Epidemiology, General Directorate of Health Services, 615 North Wolfe Street, Baltimore, Maryland 21205, Guatemala

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Robert I. AndersonDepartment of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, Onchocerciasis Section, Division of Epidemiology, General Directorate of Health Services, 615 North Wolfe Street, Baltimore, Maryland 21205, Guatemala

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Lynn Eckhert FazenDepartment of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, Onchocerciasis Section, Division of Epidemiology, General Directorate of Health Services, 615 North Wolfe Street, Baltimore, Maryland 21205, Guatemala

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Horacio Figueroa MarroquinDepartment of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, Onchocerciasis Section, Division of Epidemiology, General Directorate of Health Services, 615 North Wolfe Street, Baltimore, Maryland 21205, Guatemala

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DOI:
https://doi.org/10.4269/ajtmh.1976.25.250
Volume/Issue:
Volume 25: Issue 2
Page(s):
250–256
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This controlled study assesses the effect of a single oral dose of diethylcarbamazine (DEC) in a Guatemalan population with light infections of Onchocerca volvulus. From 8 to 24 hours after DEC, microfilariae were found with increased frequency in the urine, blood, and sputum, while the number of microfilariae per mm2 of skin decreased. The onset of signs and symptoms of reaction coincided with the appearance of microfilariae in the body fluids. Motile microfilariae were noted in the anterior chamber of the eye after the administration of diethylcarbamazine. Medication with corticosteroids appeared to reduce the symptoms of reaction without changing the laboratory results.

Author Notes

Present address: University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01605.

Copyright:
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene 1976
Accepted:
02 Aug 1975
|
Published Online:
Mar 1976
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