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Manson's Schistosomiasis; Frontiers in Vivo, in Vitro, and in the Body Politic

Thomas H. WellerDepartment of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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The honor of presenting the 40th Annual Charles Franklin Craig Lecture is deeply appreciated. The privilege is unique. Only in this lecture and in the annual presidential address does the Society grant license for utterance unchallengeable from the floor and for publication without critical review.

I have chosen the subject of schistosomiasis and will comment selectively on personal investigative interests, specifically, the cultivation in vitro of schistosomes and the detection of antigenic materials elaborated by these parasites in vivo. The work to be cited reflects my fortunate association with a succession of highly productive junior colleagues, Alfred Senft, Allen Cheever, Warren Berggren, Ronald Gold, Monte Bawden, Susan Wheeldon and Thomas Smith. Yet it would be an abuse of the Craig license if this lecture were to deal only with our own work. I will attempt to integrate the information we have accured with subsequent developments from other laboratories.