Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Evaluating New Antimalarial Drugs against Trophozoite Induced Plasmodium Cynomolgi Malaria in Rhesus Monkeys

David E. Davidson Jr.Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand

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Dennis O. JohnsenDepartment of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand

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Prayot TanticharoenyosDepartment of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand

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Robert L. HickmanDepartment of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand

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Kenneth E. KinnamonDepartment of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1976.25.26
Volume/Issue:
Volume 25: Issue 1
Page(s):
26–33
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An antimalarial drug testing system is described which utilizes trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. The schizonticidal activity of standard antimalarial drugs in this system is reported. The system accurately predicted anti-malarial activity in man of 8 of 9 compounds selected for clinical trials.

Author Notes

Department of Veterinary Medicine, SEATO Medical Research Laboratory, Bangkok.

Letterman Army Institute of Research.

U. S. Army Medical Research Institute of Infectious Diseases.

Division of Medicinal Chemistry, Walter Reed Army Institute of Research.

Copyright:
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene 1976
Accepted:
09 Jul 1975
|
Published Online:
Jan 1976
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