The Treatment of Schistosomiasis Mansoni in Murang'a District, Kenya: A Double Blind Controlled Trial of Three Hycanthone Regimens and Oxamniquine

P. H. ReesDepartment of Medicine, University of Nairobi, Nairobi, District Hospital, Murang'a, Division of Vector Borne Diseases, Nairobi, and Provincial Medical Headquarters, Central Province, Kenya

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H. N. BowryDepartment of Medicine, University of Nairobi, Nairobi, District Hospital, Murang'a, Division of Vector Borne Diseases, Nairobi, and Provincial Medical Headquarters, Central Province, Kenya

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J. M. D. RobertsDepartment of Medicine, University of Nairobi, Nairobi, District Hospital, Murang'a, Division of Vector Borne Diseases, Nairobi, and Provincial Medical Headquarters, Central Province, Kenya

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J. J. ThukuDepartment of Medicine, University of Nairobi, Nairobi, District Hospital, Murang'a, Division of Vector Borne Diseases, Nairobi, and Provincial Medical Headquarters, Central Province, Kenya

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In a pilot study designed to find the most suitable drug regimen for the mass treatment of schistosomiasis mansoni, four regimens were found equally effective. Hycanthone 1.5 mg/kg body weight in a single dose was thought to be the most satisfactory regimen in the given situation. The other regimens were oxamniquine 7.5 mg/kg, hycanthone 1.5 mg/kg given on two occasions a week apart, and hycanthone 2.25 mg/kg, all by intramuscular injection.

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