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In a pilot study designed to find the most suitable drug regimen for the mass treatment of schistosomiasis mansoni, four regimens were found equally effective. Hycanthone 1.5 mg/kg body weight in a single dose was thought to be the most satisfactory regimen in the given situation. The other regimens were oxamniquine 7.5 mg/kg, hycanthone 1.5 mg/kg given on two occasions a week apart, and hycanthone 2.25 mg/kg, all by intramuscular injection.