Effects of Portacaval shunting on Schistosoma Japonicum Infection in Chimpanzees: Dissociation of Pipe-Stem Fibrosis and Glomerulopathy

Elvio H. Sadun Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Elvio H. Sadun in
Current site
Google Scholar
PubMed Close
,
Willis A. Reid Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Willis A. Reid in
Current site
Google Scholar
PubMed Close
,
Allen W. Cheever Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Allen W. Cheever in
Current site
Google Scholar
PubMed Close
,
Rodney H. Duvall Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Rodney H. Duvall in
Current site
Google Scholar
PubMed Close
,
Kenneth G. Swan Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Kenneth G. Swan in
Current site
Google Scholar
PubMed Close
,
Kenneth M. Kent Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Kenneth M. Kent in
Current site
Google Scholar
PubMed Close
,
John I. Bruce Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by John I. Bruce in
Current site
Google Scholar
PubMed Close
, and
Franz Von Lichtenberg Department of Medical Zoology and Division of Surgery, Walter Reed Army Institute of Research, Laboratory of Parasitic Diseases, NIAID, and Cardiology Branch, NHLI, National Institues of Health, Department of Pathology, Peter Bent Brigham Hospital, Washington, D. C. 20012

Search for other papers by Franz Von Lichtenberg in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1975.24.619
Volume/Issue:
Volume 24: Issue 4
Page(s):
619–631
Restricted access
Get Permissions

Eight of 10 young chimpanzees were infected with the Japanese strain of Schistosoma japonicum. In 6 of these, and in 1 normal chimpanzee, a surgical end-to-side portacaval shunt was constructed during the 8th week of infection. One additional infected chimpanzee was treated successfully with the nitrovinylfuran, SQ 18,506. In the four animals surviving both infection and shunting hepatic portal fibrosis was either absent or mild. In the 7-month survivors and in the drug-treated control animal there was evidence of healed portal endophlebitis and arterialization, but no active schistosomal liver lesion was found. Nevertheless, three of these animals showed variable degrees of active schistosomal glomerulopathy, similar to that seen in the unshunted infected control and to that described in earlier studies. There was a shift of the egg burden from the liver to the lungs, as well as evidence that the number of surviving adult worms had decreased following portacaval shunting. These observations suggest that schistosomal nephropathy in chimpanzees is more closely related to infection intensity per se than to the degree of liver damage caused by infection.

Author Notes

Dr. Sadun died on 23 April 1974, after reviewing all essential data and findings with his co-authors. This research could not have been conducted without his extraordinary dedication and leadership.

Copyright:
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene 1975
Accepted:
04 Jan 1975
|
Published Online:
Jul 1975
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 328 95 4
Full Text Views 2 0 0
PDF Downloads 0 0 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save