Antigenic Relationships of Group a Arboviruses by Plaque Reduction Neutralization Testing

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  • Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, Connecticut 06510

Antigenic relationships of 20 group A arboviruses were assessed by the plaque reduction neutralization test, using highly specific hyperimmune mouse ascitic fluids and antisera. The existence of three complexes of group A viruses was verified. With rare exceptions, heterologous neutralization reactions were observed only among viruses in the same complex; however there were at least one or two immune reagents in each complex which were broadly cross-reactive within that complex.

Author Notes

Present address: Vector-Borne Diseases Division, Center for Disease Control, P.O. Box 2087, Fort Collins, Colorado 80522.