edited by W. H. Taliaferro, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, and J. H. Humphrey, National Institute of Medical Research, London, England. Vol. 1, x + 423 pages, illustrated. New York, London, Academic Press. 1961. $12.00
V. Evaluation of Cross-Immunity against Type 1 Dengue Fever in Human Subjects Convalescent from Subclinical Natural Japanese Encephalitis Virus Infection and Vaccinated with 17D Strain Yellow Fever Vaccine
The specificity and sensitivity of adult and larval somatic antigens and perienteric fluid of Toxocara canis and Ascaris suum were investigated by using a modified passive cutaneous anaphylaxis procedure in guinea pigs. Pooled sera from animals infected with low doses (0.01, 0.1, or 1.0 egg/g) were most reactive with the homologous larval antigen preparation. However, the Toxocara antisera were highly reactive with this antigen only, whereas the Ascaris antisera reactions could not be interpreted as being clearly positive with any of the antigen preparations. Sera from hyperinfected animals were also reactive with the homologous larval antigen. In addition, Ascaris larval antigen was reactive with Toxocara antiserum. The reciprocal relationship, i.e., reactivity of Toxocara larval antigen with Ascaris antiserum, was not apparent. In no instance did adult antigens induce reactions that could be interpreted as specific or sensitive indicators of antibody.
Present address: Infectious Disease Service, Rockford School of Medicine, 1601 Parkview Avenue, Rockford, Illinois 61111.