The Indirect Hemagglutination Test for Malaria

Evaluation of Antigens Prepared from Plasmodium falciparum and Plasmodium vivax

Henry M. MathewsCenter for Disease Control, Public Health Service, U. S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333

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Janet A. FriedCenter for Disease Control, Public Health Service, U. S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333

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I. G. KaganCenter for Disease Control, Public Health Service, U. S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333

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Soluble antigens were prepared from Plasmodium falciparum and P. vivax and were evaluated in the indirect hemagglutination test. These antigens, attached to aldehyde-fixed type “O” erythrocytes, detected antibodies in more than 91% of infections with the homologous Plasmodium species. Detection rates in infections caused by the heterologous species ranged from 72% to 76%. Positive reactions occurred in less than 2% of sera from persons without malaria infection.

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