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Immunization of Man against Falciparum and Vivax Malaria by Use of Attenuated Sporozoites
David F. Clyde
David F. Clyde
University of Maryland School of Medicine, Baltimore, Maryland 21201
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Vincent C. McCarthy
Vincent C. McCarthy
University of Maryland School of Medicine, Baltimore, Maryland 21201
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Roger M. Miller
Roger M. Miller
University of Maryland School of Medicine, Baltimore, Maryland 21201
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William E. Woodward
William E. Woodward
University of Maryland School of Medicine, Baltimore, Maryland 21201
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With strict adherence to ethical guidelines, a volunteer was immunized against sporozoites of Plasmodium falciparum and P. vivax, the antigen consisting of attenuated sporozoites of each species inoculated through bites of mosquitoes X-irradiated at a minimum dosage of 15,000 rads. On one occasion this dosage did not render all P. vivax sporozoites noninfective. Species specificity of antigen and antibody was demonstrated, but within each species a wide geographical diversity of strains proved interchangeably antigenic and susceptible to the antibody. Once immunized, the volunteer was protected for not more than 3 months and 6 months, respectively, from infective P. falciparum and P. vivax sporozoites, the duration of protection being reflected by a positive species-specific circumsporozoite reaction. Studies in this volunteer, and in two others immunized with P. falciparum sporozoites, did not reveal any increase in serum levels of immunoglobulins G and M.
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| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 3561 | 2294 | 406 |
| Full Text Views | 107 | 31 | 16 |
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