Attempted Prevention of Diarrheal Disease in Apache Children with a Non-Absorbable Broad-Spectrum Antimicrobial

Norbert HirschhornDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Norbert Hirschhorn in
Current site
Google Scholar
PubMed
Close
,
William E. WoodwardDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by William E. Woodward in
Current site
Google Scholar
PubMed
Close
,
Lois K. EvansDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Lois K. Evans in
Current site
Google Scholar
PubMed
Close
,
Grace H. ChickadonzDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Grace H. Chickadonz in
Current site
Google Scholar
PubMed
Close
,
Robert S. GordonDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Robert S. Gordon in
Current site
Google Scholar
PubMed
Close
,
R. Bradley SackDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by R. Bradley Sack in
Current site
Google Scholar
PubMed
Close
,
Mark BreutzmanDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Mark Breutzman in
Current site
Google Scholar
PubMed
Close
,
Richard A. CashDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Richard A. Cash in
Current site
Google Scholar
PubMed
Close
, and
Philip D. ZieveDepartments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, National Institute of Arthritis, Metabolism and Digestive Diseases, Baltimore, Maryland 21205

Search for other papers by Philip D. Zieve in
Current site
Google Scholar
PubMed
Close
Restricted access

A double-blind study was conducted to test the prophylactic effect of a non-absorbable broad-spectrum antimicrobial (oral colistin sulfate) against acute diarrhea in Apache children. Children 1 to 6 months old had over twice the morbidity from diarrhea if assigned to the antimicrobial group as compared to placebo, while the toddler group (7–30 months) taking the antimicrobial had somewhat less diarrhea. Enterpathogenic E. coli were significantly more often isolated from the antimicrobial group (but only in well children). No special effect on the children's growth by the antimicrobial was discerned.

Save