Long-Term Efficacy of Tubercidin against Schistosomiasis Japonica and Mansoni in Primates

J. J. Jaffe Department of Pharmacology, University of Vermont College of Medicine, Department of Pathology, Peter Bent Brigham Hospital, Burlington, Vermont 05401

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H. M. Doremus Department of Pharmacology, University of Vermont College of Medicine, Department of Pathology, Peter Bent Brigham Hospital, Burlington, Vermont 05401

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H. A. Dunsford Department of Pharmacology, University of Vermont College of Medicine, Department of Pathology, Peter Bent Brigham Hospital, Burlington, Vermont 05401

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E. Meymarian Department of Pharmacology, University of Vermont College of Medicine, Department of Pathology, Peter Bent Brigham Hospital, Burlington, Vermont 05401

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DOI:
https://doi.org/10.4269/ajtmh.1975.24.289
Volume/Issue:
Volume 24: Issue 2
Page(s):
289–297
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Schistosomiasis japonica in capuchin monkeys (Cebus apella) and schistosomiasis mansoni in baboons (Papio cyanocephalus and P. hamadryas) were completely arrested for 6 months in every infected primate receiving a single treatment with tubercidin (Tu), administered after prior absorption into 20% of their red cells. It is very likely that a single treatment with Tu sequestered in only 15% of the hosts' red cells would also be 100% effective for prolonged periods of time, but that with lower doses some relapses would be expected. Baboons with patent Schistosoma mansoni infections were rechallenged with S. mansoni cercariae 4 months after treatment with Tu. Although Tu eliminated almost all the sexually mature female worms from the primary infection but spared most of the males for continuing sojourn within their hosts, the baboons retained their full susceptibility to reinfection, as indicated by worm burdens and fecal egg excretion. However, the granulomatous reaction in the rechallenged Tu-treated baboons to new masses of eggs trapped in their livers appeared to be less intense than was seen in animals with primary infections.
Copyright:
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene 1975
Accepted:
29 Jun 1974
|
Published Online:
Mar 1975
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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